Scleroderma Insights

Women have a fivefold higher risk of developing systemic...

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Latest Research

A recent systematic review examined the prevalence of depression in patients with systemic sclerosis (SSc) using self-assessment tools such as the Beck Depression Inventory.

The review found that depression is highly prevalent among SSc patients, with rates ranging from 36% to 65%, which is significantly higher than in the general population.

Depression in these patients may result from biological, cognitive, and social factors and can negatively impact treatment adherence and social behavior.

The study highlights the importance of screening for depression in SSc patients to provide timely support and improve care.

Interestingly, specific autoantibodies associated with SSc do not seem to influence depression risk.

Addressing depression could be crucial for enhancing the quality of life for those living with systemic sclerosis Mehmetoglu et al.

(2025)
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Clinical Trials

This is a list of upcoming or ongoing clinical trials that are actively recruiting and have been listed or updated in the last two weeks:
NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Participants With Immune-Mediated Diseases (Ntrust-2)
Study Type
Phase I
Location
United States
Age Range
18 - 65 Years
Enrollment
72
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer
Study Type
Phase I
Location
2 countries
Age Range
18+ Years
Enrollment
300
A Study Evaluating the Efficacy and Safety of Vixarelimab in Participants With Idiopathic Pulmonary Fibrosis and in Participants With Systemic Sclerosis-Associated Interstitial Lung Disease
Study Type
Phase II
Location
20 countries
Age Range
18 - 85 Years
Enrollment
320
Safety and Efficacy of Baricitinib on Skin Tightening in Diffuse Cutaneous Systemic Sclerosis: A Comparative Study With Methotrexate
Study Type
Phase III
Location
Bangladesh
Age Range
18+ Years
Enrollment
24

Community News

Thriving with SclerodermaThriving with SclerodermaApr 22, 2025

It is shocking how fast scleroderma can change everything in your life!

Greater Washington DC Scleroderma FoundationGreater Washington DC Scleroderma FoundationApr 17, 2025

When you’re living with scleroderma, your hands are a barometer for how your body feels.

Tightness. Swelling. Sensitivity. Raynaud’s --- Calcinosis and Ulcers

They can make even simple tasks feel impossible.

Make sure you talk to your healthcare team about how to best care for your hands.

What’s one thing you do to soothe or support your hands?

Scleroderma and Raynaud's UKScleroderma and Raynaud's UKApr 17, 2025

When you’re living with scleroderma, your hands are a barometer for how your body feels.

Tightness. Swelling. Sensitivity. Raynaud’s --- Calcinosis and Ulcers

They can make even simple tasks feel impossible.

Make sure you talk to your healthcare team about how to best care for your hands.

What’s one thing you do to soothe or support your hands?

Upcoming Events

MAY
03
Scleroderma Patient Education Online Scleroderma Foundation of Greater Chicago • Chicago, IL
JUN
02
Scleroderma Patient Forum Online Thriving with Scleroderma • Haleiwa, HI